Ddh170 1657..1668
نویسندگان
چکیده
CRUK Beatson Laboratories, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK, Institute of Biomedical and Life Sciences, Davidson Building, University of Glasgow, Glasgow G12 8QQ, UK, Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK and Department of Pathology and Neuroscience Program, Biomedicum, 5th floor and Helsinki University Central Hospital, Haartmaninkatu, PO Box 63 (Haartmaninkatu 8), University of Helsinki, 00014 Helsinki, Finland
منابع مشابه
In vitro antimycobacterial activities of newly synthesized benzoxazinorifamycins.
Newly synthesized rifamycin derivatives, KRM-1648, KRM-1657, KRM-1668, KRM-1686, and KRM-1687, having the chemical structures of 3'-hydroxy-5'-(4-alkylpiperazinyl)-benzoxazinorifamycins (alkyl residues: isobutyl, propyl, sec-butyl, sec-butyl [R configuration], and sec-butyl [S configuration], respectively), were studied for their in vitro antimycobacterial activities. Representative (KRM-1648) ...
متن کاملIn vitro and in vivo antibacterial activities of KRM-1648 and KRM-1657, new rifamycin derivatives.
The in vitro and in vivo antibacterial activities of the new rifamycin derivatives KRM-1648 and KRM-1657 were compared with those of rifampin. Rifabutin, ciprofloxacin, and clarithromycin were also tested for reference. The respective MICs of KRM-1648 and KRM-1657 for 90% of the strains tested (MIC90S) were 0.016 and 0.0078 microgram/ml, respectively, for methicillin-susceptible Staphylococcus ...
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